infectious disease

Computational evolutionary analysis of the overlapped surface (S) and polymerase (P) region in hepatitis B virus indicates the spacer domain in P is crucial for survival

The Hepatitis B Virus (HBV) genome contains four ORFs, S (surface), P (polymerase), C (core) and X. S is completely overlapped by P and as a consequence the overlapping region is subject to distinctive evolutionary constraints compared to the …

Genetic characterization and transmitted drug resistance of the HIV type 1 epidemic in men who have sex with men in Beijing, China

A rapid increase in the number of HIV cases in the men who have sex with men (MSM) population has been observed in China; however, little information is available on the genetic characterization of HIV prevalent in this population. In this study, 95 …

Comparative proteomics reveal fundamental structural and functional differences between the two progeny phenotypes of a baculovirus

It is unclear whether there are statistically significant differences in incubation times amongst SARS‐CoV‐2, SARS‐CoV and MERS‐CoV. However, this is because 1) Limited available data challenges investigation of the current coronavirus outbreak. 2) Lack of annotation also makes it difficult to identify and consolidate the datasets. Thus, care should be taken when selecting datasets for comparative analysis with other viruses or outbreaks.

National borders effectively halt the spread of rabies: the current rabies epidemic in China is dislocated from cases in neighboring countries

China has seen a massive resurgence of rabies cases in the last 15 years with more than 25,000 human fatalities. Initial cases were reported in the southwest but are now reported in almost every province. There have been several phylogenetic …

Observation of non-principal plane neutral points in the upwelling polarized light field above a water surface

Using a digital camera and linearly polarizing film, we have developed a method for observing neutral point locations in the natural light field of the atmosphere. Utilizing this method, we have observed neutral points in the upwelling light field …

The spatial and temporal dynamics of rabies in China

Recent years have seen a rapid increase in the number of rabies cases in China and an expansion in the geographic distribution of the virus. In spite of the seriousness of the outbreak and increasing number of fatalities, little is known about the …

Emergence of genotype I of Japanese encephalitis virus as the dominant genotype in Asia

Japanese encephalitis virus (JEV), a mosquito-borne zoonotic pathogen, is one of the major causes of viral encephalitis worldwide. Previous phylogenetic studies based on the envelope protein indicated that there are four genotypes, and surveillance …