infectious disease

Genome comparison provides molecular insights into the phylogeny of the reassigned new genus Lysinibacillus

It is unclear whether there are statistically significant differences in incubation times amongst SARS‐CoV‐2, SARS‐CoV and MERS‐CoV. However, this is because 1) Limited available data challenges investigation of the current coronavirus outbreak. 2) Lack of annotation also makes it difficult to identify and consolidate the datasets. Thus, care should be taken when selecting datasets for comparative analysis with other viruses or outbreaks.

Resistant mutations and quasispecies complexity of hepatitis B virus during telbivudine treatment"

It is unclear whether there are statistically significant differences in incubation times amongst SARS‐CoV‐2, SARS‐CoV and MERS‐CoV. However, this is because 1) Limited available data challenges investigation of the current coronavirus outbreak. 2) Lack of annotation also makes it difficult to identify and consolidate the datasets. Thus, care should be taken when selecting datasets for comparative analysis with other viruses or outbreaks.

BlastGraph: a comparative genomics tool based on BLAST and graph algorithms

BlastGraph is an interactive Java program for comparative genome analysis based on Basic Local Alignment Search Tool (BLAST), graph clustering and data visualization. The software generates clusters of sequences of multiple genomes from all-to-all …

Rabies cases in the west of China have two distinct origins

In China, rabies remains an ongoing threat to public health. Although control efforts have been effective in reducing the number of annual cases, the virus continues to spread into new areas. Tibet, Qinghai, Gansu and Ningxia in western China have, …

Identifying the pattern of molecular evolution for Zaire ebolavirus in the 2014 outbreak in West Africa

The current Ebola virus disease (EVD) epidemic has killed more than all previous Ebola outbreaks combined and, even as efforts appear to be bringing the outbreak under control, the threat of reemergence remains. The availability of new whole-genome …

MicroRNA miR-21 attenuates human cytomegalovirus replication in neural cells by targeting Cdc25a

Congenital human cytomegalovirus (HCMV) infection is a leading cause of birth defects, primarily manifesting as neurological disorders. HCMV infection alters expression of cellular microRNAs (miRs) and induces cell cycle arrest, which in turn …

Does SARS‐CoV‐2 has a longer incubation period than SARS and MERS?

Rabies reemerged in China during the 1990s with a gradual increase in the number and geographical dispersion of cases. As a consequence, a national surveillance program was introduced in 2005 to investigate the outbreak in terms of vaccination …

Comparison of genotypes I and III in Japanese encephalitis virus reveals distinct differences in their genetic and host diversity

Japanese encephalitis (JE) is an arthropod-borne disease associated with the majority of viral encephalitis cases in the Asia-Pacific region. The causative agent, Japanese encephalitis virus (JEV), has been phylogenetically divided into five …

Reassortment and migration analysis of Crimean–Congo haemorrhagic fever virus

Crimean–Congo haemorrhagic fever virus (CCHFV) is a tick-borne virus with high pathogenicity to humans. CCHFV contains a three-segment [small (S), medium (M) and large (L)] genome and is prone to reassortment. Investigation of identified reassortment …

Molecular phylodynamic analysis indicates lineage displacement occurred in Chinese rabies epidemics between 1949 to 2010

Rabies remains a serious problem in China with three epidemics since 1949 and the country in the midst of the third epidemic. Significantly, the control of each outbreak has been followed by a rapid reemergence of the disease. In 2005, the government …